Indication •  Depression

•  Generalized Anxiety Disorder
•  Off-label:

•  Obsessive-Compulsive Disorder

•  Panic Disorder

•  Insomnia

•  Vasomotor Symptoms Associated with Menopause

Contraindication •  May increase suicide rates in Children and adolescent for short term (To be used with caution)

•  Hypersensitivity

•  Breastfeeding

•  Risk of switch to Mania

•  Gastrointestinal bleeding

•  Abnormal Electrocardiogram changes

•  History of seizure disorder

•  Risk of Hyponatremia

•  Angle closure glaucoma

•  Sexual dysfunction

•  Concomitant use with few other drugs like pimozide or thioridazine or Monoamine Oxidase Inhibitors, other

Benefit •  Improvement in depressive symptoms

•  Safer than other antidepressants in pregnancy and breastfeeding

•  Safe in patients with cardiac problems

•  Safe in patients taking multiple medications for other medical problems

Adverse effects

(usually decreases in 3-4 weeks of therapy, usually reversible)

•  Headache

•  Nausea

•  Ejaculation disorder

•  Somnolence

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