| Mirtazapine | |
| Indication | • Depression
• Off-label: • Posttraumatic Stress Disorder • Insomnia • Hot Flashes |
| Contraindication | • May increase suicide rates in Children and adolescent for short term (To be used with caution)
• Hypersensitivity • Breastfeeding • Risk of switch to Mania • Gastrointestinal bleeding • Abnormal Electrocardiogram changes • History of seizure disorder • Risk of Hyponatremia • Angle closure glaucoma • Sexual dysfunction • Agranulocytosis • Akathisia • Concomitant use with few other drugs like pimozide or thioridazine or Monoamine Oxidase Inhibitors, other |
| Benefit | • Improvement in depressive symptoms
• Improvement in depressive symptoms not responding to other class of antidepressants • May cause weight gain in patients with weight loss due to depression |
|
Adverse effects (usually decreases in 3-4 weeks of therapy, usually reversible) |
• Somnolence
• Weight gain • Xerostomia • Increased appetite • Constipation |
